Another vote for Brave browser. I haven't seen a YT ad since I made it my default. No other ad-blocking software. Sometimes I forget and open YT in Firefox or Chrome, and I'm immediately reminded why I like Brave.
Brave, in case you don't know, is a cousin of sorts to Chrome, based on "Chromium", whatever that is. (Open-source, I think.) It has a bunch of features that I turned off, I just want a simple web browser. Not too heinous to configure though, I just go into Settings and uncheck a bunch of boxes.
Their main schtick is being more security and privacy-oriented than some other browsers. Chrome for example is selling my eyeballs to advertizers all the time. Brave claims not to do that, I think, but I really don't know what browsers are doing under the hood or behind my back.
I use DuckDuckGo as my default search engine (again, more privacy-oriented). But I have to admit it's not as good as Google for some searches, so I switch to Google now and then when DDG doesn't seem to be finding what I want. I just know that with Google, anything I type in will come back to me as ads for that thing, which I find a bit creepy.